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Why am I being treated with eculizumab? Sometimes, it is prescribed for individuals with autoimmune myasthenia gravis (MG). Treatment with eculizumab (Soliris) continued to show sustained activity and tolerability through 3 years of follow-up for patients with anti-acetylcholine receptor (AChR) antibodyâpositive generalized myasthenia gravis (gMG), according to a presentation at the 2018 AANEM Annual Meeting. What is eculizumab? It is not known if SOLIRIS ⦠Yeo CJJ(1), Pleitez MY(1). Objective. Myasthenia Gravis is a neuromuscular disorder that impacts over 50 thousand patients in the United States (U.S.). Eculizumab in refractory myasthenic crisis. KEYWORDS: Biological drugs, complement system, eculizumab, myasthenia gravis Article highlights Eculizumab is an innovative biological drug blocking the human terminal complement protein C5 with promising activity for the treatment of AChR-positive refractory generalized MG, as demonstrated in REGAIN, a phase III ⦠James F Howard Jr. A Japanese man with generalized myasthenia gravis (gMG) experienced a severe worsening of symptoms after discontinuing treatment with Soliris (), a case study reported.. See Important Safety Information, including Boxed Warning, and full Prescribing Information. Titled â Severe worsening of myasthenic symptoms after the eculizumab discontinuation,â the case study was published in the ⦠Eculizumab is ⦠Correspondence. Prof James F Howard Jr, MD . SOLIRIS is a prescription medicine used to treat adults with a disease called generalized myasthenia gravis (gMG) who are anti-acetylcholine receptor (AChR) antibody positive. Srikanth Muppidi, MD. Generalized Myasthenia Gravis (gMG) Real-World Use of Eculizumab in Generalized Myasthenia Gravis in the United States: Results from a Pilot Retrospective Chart-Review Study. Eculizumab is a medication that suppresses the immune system. The total number of treated patients is ⦠Of those patients that are diagnosed, approximately 95 percent are treated with immunosuppressants, intravenous immunoglobulin, and/or plasma exchange. Author information: (1)Houston Methodist Neurological Institute, Houston Methodist Hospital, Texas Medical Center, Houston, Texas. Keywords eculizumab, indication, myasthenia gravis, myasthenic crisis, thymoma Introduction Generalized myasthenia gravis (gMG) is a chronic autoimmune disorder that is characterized by severe muscle weakness. Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study. 1 Findings ⦠Soliris® (eculizumab) treats anti-AChR antibody-positive gMG. To assess whether eculizumab, a terminal complement inhibitor, improves patientâ and physicianâreported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory antiâacetylcholine receptor antibodyâpositive generalized myasthenia gravis ⦠Objective To evaluate whether eculizumab helps patients with antiâacetylcholine receptorâpositive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab ⦠1 In this disease, the complement-mediated pathological membrane changes reduce the efficiency of ⦠INDICATION What is SOLIRIS? Please read the Indication and Important Safety Information for Soliris ® (eculizumab). It is manufactured as a solution for intravenous infusion under the brand name Soliris®.
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